After science teacher Mrs. Murawski announces a science project, Milo, Zack, and Melissa must overcome Murphy’s Law to protect an egg and their grades.
Milo and the gang spend the entire day chasing after his doctor’s note that excuses an entire semester of absences, illness and shenanigans caused by Murphy’s Law.
Zack, Melissa, and Milo attend an opera performance with Amanda, but Milo accidentally ends up backstage and attempts to prevent any havoc from occurring.
Milo begins to sleepwalk through some nearby woods. Meanwhile, Cavendish and Dakota have a ”ditch day” from pistachio duties after their ordeal with the Pistachions.
When Cavendish and Dakota stop Milo from destroying a pistachio plant, they change the future. Pistachio plants survive, become sentient, and take over the planet.